A Comparative Study of Soft-sensing Methods for Fed- Batch Fermentation Processes

Optimization of A Fed-Batch Fermenter Producing Baker’s Yeast Using Simulated Annealing Method

Modeling of fermentation processes is so complicated and uncertain; therefore it is necessary to provide a robust and appropriate dynamic optimization method. In order to obtain the maximum amount of yeast (Saccharomyces cerevisiae), the bioreactor must be operated under optimal conditions. To determine substrate feeding in a fed-batch bioreactor, a simulated annealing (SA) approach was examine...

Soft-sensing Modeling Based on MLS-SVM Inversion for L-lysine Fermentation Processes

A modeling approach 63 based on multiple output variables least squares support vector machine (MLS-SVM) inversion is presented by a combination of inverse system and support vector machine theory. Firstly, a dynamic system model is developed based on material balance relation of a fed-batch fermentation process, with which it is analyzed whether an inverse system exists or not, and into which ...

Evaluation of Heat Induction Strategy for Recombinant Human Growth Hormone Expression in Fed-Batch Fermentation

Intelligent Software Sensors for Fed-Batch Fermentation Processes

Software sensors have attracted great research interests due to the problem of lacking suitable and robust online sensors for key fermentation variables in fed-batch fermentation processes. In this paper, intelligent software sensors have been developed based on multivariate statistical process control methods. The software sensors not only provide real time estimation of key variables but also...

Design of On-line State Estimators for a Recombinant E. Coli Fed-batch Fermentation

In recent years a remarkable effort has been made in the development of new sensors and process analytical technology. However, it is still difficult to find reliable and low cost commercial sensors for on-line measurements of important variables. Therefore, considerable attention has been focused on the development of on-line software sensors. Nevertheless, the application of those algorithms ...